11/12/2022 0 Comments Cis 9 trans 11 musclepharmPractical applications: CLAs have been shown to occur naturally in food. CLA isomers have no effect on atherosclerosis in apoE/LDLR−/− mice. In conclusion, our results do not support the notion that CLA isomers supplementation to the diet has anti‐atherosclerotic effects. There were no isomer‐specific effects of CLA isomers on the area of atherosclerotic plaque. Only c9,t11 increased ACO level in LONG experiment. The expression of their target genes like ACO (PPARα) or FAS (SREBP‐1) were not changed. In mice receiving the CLA isomers the level of PPARα and SREBP‐1 mRNA in liver were significantly decreased. In LONG experiment, t10,c12 CLA significantly (p<0.05) increased plasma TAGs, whereas no such effect was observed in SHORT one. In mice fed t10,c12 CLA weight of liver was threefold (p<0.05) increased what was linked with hepatic steatosis observed in LONG and SHORT experiment. In both experiments, c9,t11 CLA increased mice body weight. In a “short experiment” (SHORT), 4‐month‐old mice, with pre‐established atherosclerosis, were randomly assigned to three experimental groups and fed for the next 2 months. In a “long experiment” (LONG), 2‐month‐old mice with no atherosclerosis were randomly assigned to three experimental groups and fed for the next 4 months. Additionally, the effect of CLA isomers on liver steatosis was observed. The objective of our studies was to verify the potential health‐related, anti‐atherogenic potency of CLA isomers, fed to apolipoprotein E and LDL receptor double knockout mice (apoE/LDLR−/−), representing a reliable model of atherogenesis. Maślak, Edyta Franczyk‐Żarów, Magdalena Gajda, Mariusz Chłopicki, Stefan Effects of trans ‐10, cis ‐12 and cis ‐9, trans ‐11 CLA on atherosclerosis in apoE/LDLR −/− mice Effects of trans ‐10, cis ‐12 and cis ‐9, trans ‐11 CLA on atherosclerosis in apoE/LDLR −/− mice
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